Search results for "Muller cell"

showing 1 items of 1 documents

Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat

2012

Purpose: Our previous studies suggested that CYP46A1 and 24S-hydroxycholesterol. (24SOH) may be associated with glaucoma. Loss of CYP46A1-expressing retinal. ganglion cells is involved in the activation of glia, and therefore possibly in the. disbalance of cholesterol. In this context, the purpose of our present work was to. emphasize the glial and longitudinal CYP46A1 expression after an interventional. glaucoma-related stress triggered by elevated intraocular pressure (IOP). Methods: Sprague–Dawley rats were submitted to laser photocoagulation of the. trabecular meshwork, limbus and episcleral veins in one eye to induce elevated IOP. Rats were euthanized at days 3, 14, 30 and 60 (n = 10 p…

Intraocular pressuregenetic structures[ SDV.AEN ] Life Sciences [q-bio]/Food and NutritionGlaucomacholesterol homeostasisRats Sprague-Dawleychemistry.chemical_compound0302 clinical medicineHomeostasis0303 health sciencesGeneral MedicineAnatomyGanglionmedicine.anatomical_structureCytokinesIntercellular Signaling Peptides and Proteinsmedicine.symptomNeurogliamedicine.medical_specialtyBlotting WesternContext (language use)BiologyGas Chromatography-Mass SpectrometryRetina03 medical and health sciencesOphthalmologyGlial Fibrillary Acidic ProteinCholesterol 24-HydroxylasemedicineAnimalsIntraocular Pressure030304 developmental biologyRetinaRetinalmedicine.diseaseHydroxycholesterolseye diseasesRatsDisease Models AnimalOphthalmologyglaucomagliosisGliosischemistrySteroid Hydroxylases030221 ophthalmology & optometryOcular HypertensionMuller cellTrabecular meshworksense organs[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
researchProduct